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Designer T cells fight viruses after transplants
"It's just very, very hard and very expensive to generate cells from each transplant donor against each virus," he said. Nike Air Max 2017 For Men
Different varieties of custom made T cells have proved effective in a series of small studies, added Dr. Richard O'Reilly, pediatrics chief at Memorial Sloan Kettering Cancer Center and another pioneer of the approach.
"What this is showing is that you can make T cells against a series and these are the most important viruses that we deal with and you can make enough of these T cells to make a difference."
To see if they worked, Leen's team treated 11 transplant recipients. Eight had active Nike Air Max Jd
It would take large studies to prove such a system really works.
But Leen's technique makes production of these T cells practical instead of laborious, said Dr. John Barrett of the National Institutes Health, who wasn't involved with the new research.
"These viruses are a huge problem, and there's a huge need for these products," said Dr. Ann Leen, who leads a team at Baylor College of Medicine and Texas Children's Hospital that found an easier way to produce these long desired designer T cells.
"It's a step further to making this something that could be done not just in ivory towers," but one day by a drug company, said Barrett, a stem cell transplant specialist at NIH's National Heart, Lung and Blood Institute.
Next, her team is beginning a bigger step to try creating a bank of those cells from a variety of healthy donors that any patient could use, without having to custom brew each dose.
Essentially, Leen came up with a recipe to stimulate donated T cells in the laboratory so that they better recognize those particular viruses, and then grow large quantities of the cells. It took just 10 days to create and freeze the designer T cells.
infections, most with multiple viruses. The cell therapy proved more than 90 percent effective, nearly eliminating all the viruses from the blood of all the patients, Leen reported in the journal Science Translational Medicine.
The other three patients weren't sick but were deemed at high risk. They were given early doses of the T cells protectively and remained infection free, Leen said.
with suppressed immune systems such as those undergoing a bone marrow transplant to treat leukemia or other diseases lack that protection. It can take anywhere from four months to more than a year for marrow stem cells from a healthy donor to take root and start producing new immune cells for the recipient. When patients get sick before then, today's antiviral medications don't always work and cause lots of side effects.
Wednesday, Leen reported a novel technique to rapidly manufacture so called virus specific T cells that can target up to five of the viruses that cause the most trouble for transplant patients: Epstein Barr virus, adenovirus, cytomegalovirus, BK virus, and human herpesvirus 6.
Healthy people have an army of T cells that roams the body, primed to recognize and fight viruses. People Nike Air Max Og Blue
The proposed solution: Take certain virus fighting T cells from that same bone marrow donor, and freeze them to use if the recipient gets sick. Years of experiments show it can work. But turning the idea into an easy to use treatment has been difficult. A dose had to be customized to each Air Max Sneakers 2016 donor recipient pair and protected against only one or two viruses. And it took as long as three months to make.
WASHINGTON (AP) Bone marrow transplants save thousands of lives but patients are vulnerable to severe viral infections in the months afterward, until their new immune system kicks in. Now scientists are developing protection for that risky period injections of cells specially designed to fend off up to five different viruses at once.
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